The ability to stimulate specific physiological and performance adaptations is in large part predicated by the ability to vary the training stimuli and induce novel stimuli at appropriate times. One new method for introducing training variation,while maximizing the velocity and power output of the training exercise is the utilization of a cluster set configuration. This review takes the theoretical and scientific foundation about the use of the cluster set and offers examples ofhow this unique training tool can be applied to the preparation of athletes from various sports.